Though a childhood bout with polio left him dependent on an iron lung, Mark O’Brien (John Hawkes) maintains a career as a journalist and poet. A writing assignment dealing with sex and the disabled piques Mark’s curiosity, and he decides to investigate the possibility of experiencing sex himself. When his overtures toward a caregiver scare her away, he books an appointment with sex surrogate Cheryl Green (Helen Hunt) to lose his virginity.
A young autistic woman runs away from her caregiver in order to boldly go and deliver her 500-page Star Trek script to a writing competition in Hollywood. On an adventure full of laughter and tears, Wendy follows the guiding spirit of Mr. Spock on her journey into the unknown.